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. 2019 Nov 7;9(1):1672495. doi: 10.1080/2162402X.2019.1672495

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© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Representative images of grade 1–3 tumor budding and the prognostic role of tumor budding in training and validation cohorts. (a–c), Representative images of grade 1–3 tumor budding. (d), Survival analysis comparing overall survival (OS) between tumor budding (TB)-grade-high and TB-grade-low groups in the training cohort. (e), Disease-free survival (DFS) analyses in the training cohort. (f), the forest map showed that TB was an adverse prognostic factor for both OS and DFS in the training cohort after adjusting confounding factors. (g–h), Survival analysis comparing OS (G) and DFS (H) between tumor TB-grade-high and TB-grade-low groups in the validation cohort. (i), the forest map showed that TB was an adverse prognostic factor for both OS and DFS in the validation cohort. AFP, alpha fetoprotein; HBV, hepatitis-B virus; ALBI, albumin-bilirubin; BCLC, Barcelona Clinic Liver Cancer staging system; MVI, microvascular invasion.