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. 2020 Jan 13;9(1):1710052. doi: 10.1080/2162402X.2019.1710052

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Forest plot representing the odds ratio for high-grade toxicities (A), and for treatment-related mortality (B) for experimental arms with combination of therapies compared to experimental arms with single-agent non-cytotoxic therapies. Studies are labeled by first author’s last name and year of publication and numbers in brackets are labeled according to supplementary references. Panel A shows odds ratio (95% confidence interval) for high-grade toxicities for each randomized trial comparing combinations to single agents. The plot shows an overall increase in high-grade toxicities for combinations: OR (95% CI) = 2.42 (1.98−2.97) (p < .001). Panel B shows odds ratio (95% confidence interval) for treatment-related mortality for each randomized trial comparing combinations to single agents. The plot shows an overall increase in treatment-related mortality for combinations: OR (95% CI) = 1.33 (1.15–1.53) (p < .001).

Abbreviations: CI: confidence interval; Non-Tox: number of patients without high-grade toxicities; OR: odds ratio; Tox: number of patients with high-grade toxicities: RE model: random-effects model.