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. 2019 Dec 18;56(2):508–521. doi: 10.3892/ijo.2019.4946

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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LINC00473 promotes glioma progression through miR-195-5p-mediated YAP1-TEAD1-Hippo signaling pathway. (A) The influence of sh-LINC00473 and miR-195-5p inh on cell viability was detected by Cell Counting Kit-8. (B) The influence of sh-LINC00473 and miR-195-5p inh on apoptosis was detected by flow cytometry. (C) The influence of sh-LINC00473 and miR-195-5p inh on cell cycle progression, specifically G1, was detected by flow cytometry. LINC00473 promotes glioma progression through miR-195-5p-mediated YAP1-TEAD1-Hippo signaling pathway. (D) The influence of sh-LINC00473 and miR-195-5p inh on cell migration as determined by wound healing assay. (E) The influence of sh-LINC00473 and miR-195-5p inh on cell invasion was detected by Transwell assay. (F) The influence of sh-LINC00473 and miR-195-5p inh on protein expression levels of YAP1, TEAD1 and CTGF were determined by western blotting. ^*P<0.05 and ^**P<0.01 vs. inh NC + sh-NC; ^#P<0.05 and ^##P<0.01 vs. inh NC + sh-NC; ^&P<0.05 and ^&&P<0.01 vs. inh NC + sh-LINC00473. CTGF, connective tissue growth factor; inh, inhibitor; miR, microRNA; NC, negative control; sh, short hairpin RNA; TEAD1, TEA domain family member 1; YAP1, Yes-associated protein 1.

LINC00473 promotes glioma progression through miR-195-5p-mediated YAP1-TEAD1-Hippo signaling pathway. (A) The influence of sh-LINC00473 and miR-195-5p inh on cell viability was detected by Cell Counting Kit-8. (B) The influence of sh-LINC00473 and miR-195-5p inh on apoptosis was detected by flow cytometry. (C) The influence of sh-LINC00473 and miR-195-5p inh on cell cycle progression, specifically G1, was detected by flow cytometry. LINC00473 promotes glioma progression through miR-195-5p-mediated YAP1-TEAD1-Hippo signaling pathway. (D) The influence of sh-LINC00473 and miR-195-5p inh on cell migration as determined by wound healing assay. (E) The influence of sh-LINC00473 and miR-195-5p inh on cell invasion was detected by Transwell assay. (F) The influence of sh-LINC00473 and miR-195-5p inh on protein expression levels of YAP1, TEAD1 and CTGF were determined by western blotting. ^*P<0.05 and ^**P<0.01 vs. inh NC + sh-NC; ^#P<0.05 and ^##P<0.01 vs. inh NC + sh-NC; ^&P<0.05 and ^&&P<0.01 vs. inh NC + sh-LINC00473. CTGF, connective tissue growth factor; inh, inhibitor; miR, microRNA; NC, negative control; sh, short hairpin RNA; TEAD1, TEA domain family member 1; YAP1, Yes-associated protein 1.