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OPD' induces necroptosis in a RIPK1-dependentmanner. (A) Western blotting was used to examine the protein expression of RIPK1, cleaved-RIPK1, caspase 8 and cleaved-caspase 8 following treatment with OPD' for 6 h. (B) Annexin V-FITC/PI staining was used to analyze the LNCaP cell status after treatment with OPD' and/or Nec-1 (n=3). *P<0.05. OPD', Ophiopogonin D'; Nec-1, necrostatin-1; RIPK1, receptor-interacting serine/threonine-protein kinase 1; PI, propidium iodide; C, cleaved.
