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. 2019 Dec 17;56(2):439–447. doi: 10.3892/ijo.2019.4945

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Copyright: © Lu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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OPD' determines the pattern of cell death mediated by FADD. (A) The baseline FADD protein expression in LNCaP, PC3 and DU145 cells was examined by western blotting. (B) LNCaP, PC3 and DU145 cells were treated with OPD' for 6 h, and FADD protein expression was examined by western blotting. (C) Annexin V-FITC/PI staining was used to analyze the apoptotic rates of LNCaP cells following treatment with OPD' and siRNA-FADD (n=3). (D) The Cell Counting Kit-8 assay was used to analyze the viability of LNCaP and PC3 cells following treatment with OPD' and NAC (n=3). ^*P<0.05. OPD', Ophiopogonin D'; FADD, Fas-associated death domain; siRNA, small interfering RNA; C, siRNA-control; siRNA-F1, siRNA-FADD#1; siRNA-F2, siRNA-FADD#2; PI, propidium iodide; NAC, N-acetylcysteine.