Fig. 5.

H&E staining of liver and small intestine after chronic zebularine treatment of Min mice. Min mice were given 0.2 mg/mL zebularine dissolved in 3% sucrose water daily for 113 ± 3 d. Mice were sacrificed at day 120. The liver was washed in PBS several times. The gastrointestinal tract was removed, cut longitudinally, and washed in PBS. H&E-stained tissue sections were assessed for histologic abnormalities. Liver: untreated male (A), treated male (B), untreated female (C), and treated female (D); small intestine: untreated male (E), treated male (F), untreated female (G), and treated female (H).