Table 1.

Genes up-regulated or down-regulated in mouse colonic epithelial cells after zebularine treatment

Biological process	Gene symbol	Probe ID	Description
(A) Genes up-regulated in colonic epithelial cells after chronic zebularine treatment of the Min mice
Peptide cross-linking	Tgm2	1455900_X_AT	transglutaminase 2
		1433428_X_AT
		1437277_X_AT
Digestion	Ppy	1420440_AT	pancreatic polypeptide
	Akr1b10	1448894_AT	aldo-keto reductase family 1, member B10 (aldose reductase)
	Fabp2	1418438_AT	fatty acid binding protein 2, intestinal
Acute-phase response	Reg3a	1448290_AT	regenerating islet-derived 3α
		1416297_S_AT
	Reg3g	1448872_AT	regenerating islet-derived 3 γ
Regulation of cell adhesion	Tgm2	1455900_X_AT	transglutaminase 2
		1433428_X_AT
		1437277_X_AT
Arginine metabolism	Ddah1	1429298_AT	dimethylarginine dimethylaminohydrolase 1
	Otc	1420525_A_AT	ornithine carbamoyltransferase
Urea cycle intermediate metabolism	Ddah1	1429298_AT	dimethylarginine dimethylaminohydrolase 1
	Otc	1420525_A_AT	ornithine carbamoyltransferase
Aldehyde metabolism	Aldh1a1	1416468_AT	aldehyde dehydrogenase 1 family, member A1
	Akr1b10	1448894_AT	aldo-keto reductase family 1, member B10 (aldose reductase)
(B) Genes down-regulated in colonic epithelial cells after chronic zebularine treatment of the Min mice
Peptide cross-linking	Tgm3	1440150_AT	transglutaminase 3
Digestion	Slc15a1	1419343_AT	solute carrier family 15 (oligopeptide transporter), member 1
	Ctse	1418989_AT	cathepsin E
Regulation of cell adhesion	Lama3	1427512_A_AT	laminin, α3
Iron ion homeostasis	Slc40a1	1417061_AT	solute carrier family 40 (iron-regulated transporter), member 1
		1447227_AT

NOTE: Min mice were given 0.2 mg/mL zebularine dissolved in 3% sucrose-water daily for 113 ± 3 d. Mice were sacrificed on day 120. RNA from colonic epithelial cells was subjected to microarray analysis and analyzed using S-score algorithm (P < 10⁻⁵). An L2L array was used to obtain biological processes that were significantly affected (29).