Fig 6. The in vivo efficacy of LMM11 in systemic C. krusei candidiasis.

Mice were infected with C. krusei ATCC 6258 (1x10⁶ cells) and separated into three groups (n = 5): control (treated with PBS and the diluent), FLC (treated with fluconazole at 5 mg/kg) and LMM11 (treated with LMM11 at 5 mg/kg). Drugs were given to the mice twice a day for 5 days via intraperitoneal injection. (A) Colony forming units (log₁₀ CFU) per gram of kidney. LMM11 significantly reduced the renal fungal burden in relation to the control and FLC (*p<0.05). The bars indicate the standard deviation. (B) Kidney histological sections after Gomori-Grocott staining to indicate the presence of yeast (white arrow) only in the control group. (C-E) Histological sections stained with hematoxylin and eosin showing inflammatory infiltrate (black arrow) in the control (C), FLC (D) and LMM11 (E). Representative kidney histopathological sections from 5 mice per group.