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. 2019 Aug 21;87(1):104–111. doi: 10.1038/s41390-019-0541-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Comparison of change in a height and b−d range of motion in treated participants compared to historic MPS IH control data. Blue connected circles indicate participants who did not develop high antidrug antibodies during the study. Red connected squares indicate participants who did develop high antidrug antibodies with neutralizing antibodies during the study. Historic male and female control data are shown in gray and includes linear mean trajectory with 95%CI shown by shaded area