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. 2019 Aug 21;87(1):104–111. doi: 10.1038/s41390-019-0541-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Heatmap of outcomes for each individual participant. Green indicates more positive response to treatment, red a more negative response to treatment, and white with X indicates missing data. A “⁺” indicates that the participant developed high antidrug antibodies with neutralizing antibodies during the study. 6MWT 6-min walk test, TM treadmill, SDS standard deviation score. 6MWT grading based on previously reported change in 6MWT with long-term laronidase treatment³³