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. 2020 Jan 8;11:356. doi: 10.3389/fnagi.2019.00356

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Copyright © 2020 Chen, Shu and Zeng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The potential effect of adiponectin to target diseases and the relationship between them. As demonstrated here, adiponectin has pleiotropic effects on numerous organs and tissues, and there is a close correlation between various diseases. For example, hypertension, atherosclerosis, diabetes, and obesity are risk factors in both dementia and coronary heart disease, while hypertension, atherosclerosis, and obesity are associated with the onset of diabetes. Adiponectin has anti-atherogenic, glucose metabolism-regulating, anti-inflammatory, insulin-sensitizing, and cardioprotective effects in multiple diseases.