Table 2.
Top 10 adverse effects (all grades).
| All grades adverse effects |
Twice-daily arm (event/total) | Once-daily arm (event/total) | The incidence of adverse effects (%)a | RR (95% CI) | P-value | Heterogeneity | |
|---|---|---|---|---|---|---|---|
| I2 (%) | P-value | ||||||
| Total | 204/206 | 202/203 | 99.27 | 1.00 [0.98, 1.01] | 0.57 | - | - |
| Myelotoxicityb | 199/206 | 201/203 | 97.80 | 0.98 [0.95, 1.00] | 0.10 | - | - |
| Leukopenia | 197/206 | 190/203 | 94.62 | 1.02 [0.98, 1.07] | 0.36 | - | - |
| Fatigue | 243/266 | 247/263 | 92.63 | 0.97 [0.93, 1.02] | 0.26 | - | - |
| Neutropenia | 421/472 | 396/466 | 87.10 | 1.05[1.00, 1.10] | 0.05 | 0 | 0.36 |
| Anemia | 401/472 | 390/466 | 84.33 | 1.02 [0.96, 1.07] | 0.59 | 0 | 0.70 |
| Esophagitis | 365/460 | 315/499 | 74.81 | 1.19 [0.75, 1.90] | 0.46 | 96 | <0.00001 |
| Nausea | 195/266 | 197/263 | 74.10 | 0.98 [0.88, 1.08] | 0.68 | - | - |
| Thrombocytopenia | 134/206 | 125/203 | 63.33 | 1.06 [0.91, 1.22] | 0.47 | - | - |
| Weight loss | 136/206 | 118/203 | 62.10 | 1.14 [0.98, 1.32] | 0.10 | - | - |
| Anorexia | 153/266 | 150/263 | 57.28 | 1.01 [0.87, 1.17] | 0.91 | - | - |
RR, risk ratio; CI, confidence interval.
a
Event (twice-daily arm + once-daily arm)/Total (twice-daily arm + once-daily arm).
b
Myelotoxicity was defined as any decrease in marrow-derived cells in the peripheral-blood counts.