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. 2020 Jan 8;13:568. doi: 10.3389/fncel.2019.00568

Figure 1.

Figure 1

UPRmt response activated during the Alzheimer disease (AD) process in vitro and in vivo. (A) Western blot analysis of UPRmt related proteins level in SHSY5Y cells treated with different concentrations of Aβ25–35 for 24 h and quantification, GAPDH served as the internal control. (B) Western blot analysis of UPRmt related proteins level in SHSY5Y cells treated with 20 μM Aβ25–35 for 4 h, quantification and β-Actin served as the internal control. The data are mean ± SEM (n = 3, *p < 0.05 vs. control group). (C) Western blot analysis of UPRmt related proteins level in C57 and APP/PS1 transgenic mice at 3 and 9 months, quantification and β-Actin served as the internal control. The data are mean ± SEM (n = 10, *p < 0.05 vs. age-matched C57 mice group, #p < 0.05).