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. 2020 Jan 8;13:568. doi: 10.3389/fncel.2019.00568

Figure 5.

Figure 5

Inhibition of the sphingolipid biosynthesis pathway by SPTLC-1 siRNAs changes the mitochondrial structure, increases the intracellular ROS level and aggravates the cytotoxic effect of Aβ25–35 in SHSY5Y cells. After transfected with SPTLC-1 siRNAs for 48 h and 20 μM Aβ25–35 for 1 h, the mitochondrial structure of SHSY5Y cells was observed by a electron microscope (A), the intracellular ROS level was measured by DCFH (B), viability of the cells was examined by CCK8 assay (C). The data are mean ± SEM (n = 3, *p < 0.05).