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. 2020 Jan 8;6:186. doi: 10.3389/fcvm.2019.00186

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Copyright © 2020 Maejima.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Physiology of glucose reabsorption in the renal proximal tubules and the target of SGLT2 inhibitors. GLUT, glucose transporter; KCNE1, potassium voltage-gated channel Isk-related family member 1; KCNQ1, potassium voltage-gated channel KQT-like subfamily member 1; NHE, Na⁺/H⁺ exchanger; NKA, Na⁺/K⁺ ATPase; SGLT, sodium-dependent glucose transporter. (B) Chemical structural formulas of Phlorizin and SGLT2 inhibitors (Dapagliflozin, Empagliflozin, Canagliflozin, Ipragliflozin, Tofogliflozin, and Luseogliflozin).