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. 2020 Jan 8;6:186. doi: 10.3389/fcvm.2019.00186

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Copyright © 2020 Maejima.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hypothesized mechanism of the modulation of mitochondrial dynamics by SGLT2 inhibitors. The inhibition of SGLT2 might be associated with the mitochondrial dynamics through the regulation of (A) mitochondrial fusion and (B) mitochondrial fission. However, the detailed mechanism as to how SGLT2 inhibitors modulate the regulators of mitochondrial dynamics is largely unknown. AMPK, AMP-activated protein kinase; Drp1, Dynamin-related protein 1; Fis1, Mitochondrial fission 1 protein; Mfn, Mitofusin; Ser, Serine.