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. 2020 Jan 8;10:1512. doi: 10.3389/fphar.2019.01512

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Copyright © 2020 Wu, Lin, Wang, Li, Liu, Ye, Huang, Lin, Liu, Zhang, Li, Zhao, Lv, Li, Wang and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Krüppel-like factor 4 (KLF4) expression was decreased in human non-small-cell lung cancer (NSCLC) tissues. Immunohistochemistry was performed to evaluate the expression of KLF4. Tissue sections with (A) <30% of cells stained positive in the microscopic field, (B) 30-60% stained positive, and (C) >60% stained positive. Tissue sections with (D) mild staining, (E) moderate staining, and (F) intense staining. (G–I) Subcellular localization of KLF4.Tissue sections with (G) positive staining in the cytoplasm, (H) positive staining in the nucleus and cytoplasm, (I) positive staining in the nucleus. (J) No positive staining in the nucleus and cytoplasm. (K) KLF4 staining in adjacent normal tissues. (L) Quantitative analysis demonstrating a signiﬁcant decrease of KLF4 expression in the tumor tissues compared with adjacent normal tissues. Data presented are means ± SD. **p < 0.05.