Table 6.

Analysis of the coagulation of male and female cat blood fed AFD1 (mean ± SD).

	Study day	AFD1 level				Reference ranges
		0 ppm	7 ppm	39 ppm	66 ppm
Males
APTT (s)	−7	11.84 ± 1.12	11.86 ± 0.92	12.14 ± 0.87	11.28 ± 0.77	11.2–16.0#
	100	12.48 ± 1.56	11.74 ± 0.82	12.00 ± 0.97	11.66 ± 0.73
	182	11.88 ± 0.49	12.36 ± 0.63	12.02 ± 0.56	11.96 ± 0.55
PT (s)	−7	11.14 ± 0.47	11.06 ± 0.57	11.48 ± 0.54	11.52 ± 0.52	10.0–15.3#
	100	12.18 ± 0.68	11.46 ± 0.83	12.00 ± 0.73	11.34 ± 0.56
	182	11.18 ± 0.29	11.24 ± 0.70	11.48 ± 0.36	11.46 ± 0.63
TT (s)	−7	16.20 ± 0.92	16.62 ± 0.57	15.66 ± 0.52	16.46 ± 1.01	13.4–19.1##
	100	15.76 ± 0.80	17.30**± 1.02	17.42**± 0.93	17.44**± 0.56
	182	17.26 ± 1.23	17.46 ± 0.68	17.06 ± 0.98	17.42 ± 0.99
Females
APTT (s)	−7	11.70 ± 1.38	11.72 ± 0.71	11.56 ± 0.68	11.94 ± 0.67	11.2–16.0#
	100	13.76 ± 1.23	12.16**± 0.52	11.70**± 0.41	12.40**± 0.92
	182	12.38 ± 0.24	12.48 ± 0.75	12.24 ± 0.18	12.22 ± 1.01
PT (s)	−7	12.26 ± 0.82	12.20 ± 1.75	11.76 ± 0.71	12.08 ± 0.75	10.0–15.3#
	100	13.08 ± 0.36	11.86*± 0.61	12.32*± 0.76	12.24*± 0.87
	182	11.78 ± 0.89	12.04 ± 0.62	12.08 ± 0.41	11.94 ± 0.87
TT (s)	−7	16.66 ± 1.34	17.22 ± 1.36	15.92 ± 1.08	15.68 ± 0.61	13.4–19.1##
	100	16.06 ± 0.70	18.26*± 0.83	16.36 ± 0.63	16.30*± 0.99
	182	18.12 ± 0.70	17.84*± 0.67	16.82*± 0.44	16.56**± 0.59

AFD1, anti-Fel d 1 IgY; APTT, Activated Partial Thromboplastin Time; PT, Prothrombin Time; TT, Thrombin Time.

^*Significant at P < 0.05 when compared to the control group within a study day;

^**Significant at P < 0.01 when compared to the control group within a study day;

^#UC Davis (21);

^##Engelen et al. (22).

SD, Standard deviation.