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. 2020 Jan 8;10:1485. doi: 10.3389/fphar.2019.01485

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Copyright © 2020 Qin, Ren, Yuan, Chen, Lu, Li, Zhang, Chen and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cellular total platinum (A) and intact oxaliplatin (B) over time with 200 μm oxaliplatin exposure to HCT-116 and LOVO cell lines. Uptake of total platinum (C) and intact oxaliplatin (D) in HCT-116 and LOVO cell lines at different medium concentrations of oxaliplatin (20–500 μM) for 30 min incubation. The cellular total platinum (E) and oxaliplatin (F) uptake as a function of treatment temperature with 200 μm oxaliplatin exposure to HCT-116 and LOVO cell lines for 30 min. All data are presented as mean ± sd (n = 3). The uptake difference between two groups at 4^◦C and 37^◦C was highly significant (***P < 0.001).