Table 1.

The pharmacokinetic parameters of intact platinum-based drugs in in blood, plasma and ultrafiltrate plasma after intraperitoneal injection of equal moles of three platinum-based drugs to rats (16.7 nmol/kg).

Samples	ID	T1/2	Tmax	Cmax	AUC0-72h	Vz	Cl
	Intact drug	hr	hr	mmol/L	hr*mmol/L	L/kg	L/hr/kg
Blood	cisplatin	0.30 ± 0.02	0.08 ± 0.00	3.46 ± 0.97	2.66 ± 0.53	0.0028 ± 0.0006	0.0064 ± 0.0012
	carboplatin	2.04 ± 0.13	0.50 ± 0.00	9.90 ± 0.45	14.91 ± 1.04	0.0033 ± 0.0004	0.0011 ± 0.0001
	oxaliplatin	0.55 ± 0.04	0.08 ± 0.00	0.42 ± 0.06	0.34 ± 0.04	0.0408 ± 0.0058	0.0490 ± 0.0066
Plasma	cisplatin	0.28 ± 0.03	0.08 ± 0.00	7.86 ± 1.59	5.53 ± 0.75	0.0012 ± 0.0002	0.0030 ± 0.0004
	carboplatin	1.95 ± 0.12	0.50 ± 0.00	11.15 ± 0.49	16.85 ± 1.14	0.0028 ± 0.0003	0.0001 ± 0.0000
	oxaliplatin	0.18 ± 0.00	0.08 ± 0.00	3.90 ± 0.34	2.44 ± 0.23	0.0018 ± 0.0001	0.0069 ± 0.0006
	cisplatin	0.26 ± 0.02	0.17 ± 0.18	11.45 ± 1.46	8.33 ± 0.70	0.0008 ± 0.0001	0.0020 ± 0.0002
Ultrafiltrate plasma	carboplatin	1.52 ± 0.49	0.42 ± 0.19	10.12 ± 0.75	13.92 ± 2.48	0.0027 ± 0.0009	0.0012 ± 0.0002
	oxaliplatin	0.18 ± 0.01	0.08 ± 0.00	3.93 ± 0.45	2.40 ± 0.47	0.0019 ± 0.0006	0.0072 ± 0.0017

^*All data are presented as mean ± sd (n = 6).