Table 1.

PANSS and CGI-S, within-subjects pairwise comparisons; significance between successive time-points; *p < 0.05; **p < 0.01; ***p < 0.001.

	Estimated Marginal Means ± SE	Estimated Lower – Upper Bounds	Pairwise Comparison (p)
PANSS positive
Baseline	24.31±1.34	21.60 – 27.03
3 months	23.38±1.44	20.47 – 26.30	0.128
6 months	20.98±1.27	18.41 – 23.55	0.001**
9 months	19.20±1.22	16.75 – 21.66	0.003**
12 months	16.95±1.18	14.55 – 19.34	<0.001***
PANSS negative
Baseline	30.17±1.56	27.02 – 33.32
3 months	27.86±1.58	24.66 – 31.06	<0.001***
6 months	24.65±1.34	21.92 – 27.35	<0.001***
9 months	22.42±1.26	19.81 – 25.03	<0.001***
12 months	19.74±1.26	17.19 – 22.30	<0.001***
PANSS general psychopathology
Baseline	64.89±2.57	59.70 – 70.07
3 months	59.37±2.92	53.48 – 65.26	<0.001***
6 months	54.11±2.70	48.67 – 59.56	<0.001***
9 months	50.11±2.66	44.74 – 55.48	<0.001***
12 months	45.81±2.70	40.37 – 51.25	<0.001***
CGI-S
Baseline	5.81±0.11	5.59 – 6.04
3 months	5.47±0.13	5.20 – 5.73	0.001**
6 months	4.91±0.14	4.62 – 4.90	<0.001***
9 months	4.58±0.16	4.25 – 4.90	0.003**
12 months	4.20±0.21	3.77 – 4.62	p = 0.001**

CGI-S, Clinical Global Impressions Scale-Severity; PANSS, Positive And Negative Syndrome Scale; SE, standard error.