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. 2020 Jan 8;10:1503. doi: 10.3389/fphar.2019.01503

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Copyright © 2020 Si, Wang, Liu, Zhou, Xiang, Zhang, Wang, Feng, Xu, Yu, Zhao and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Eth inhibits tumor growth in murine models and shows favorable pharmacokinetic profiles. (A–B): Murine models were treated with vehicle, Eth (2 mg/kg) and the tumor volumes were calculated twice a week. **P < 0.01. (C): Images of xenograft tumors obtained from mice with different treatment after about 4 weeks. (D–E): Weight of the tumor from each group taken out from the sacrificed mice at the end of the study **P < 0.01. (F–G) Eth treatment did not affect the murine model body weight. (H–I): The expressions of LC3-II, AMPKα, and pAMPKα in xenograft tumor tissues were analyzed by western blot. (J): The concentration-time profiles of Eth after i.v. injection (2 mg/kg) in Sprague-Dawley rats. (K): The concentration-time profiles of Eth after i.g. injection (15 mg/kg) in Sprague-Dawley rats.