Table 1.
Kyoto Encyclopedia of Genes and Genomes pathway enrichment of differentially methylated genes and differently expressed genes.
| KEGG pathway of DMGs (IDs) | Number of DMGs involved | P value | Overlapped genes | KEGG pathway of DEGs (IDs) | Number of DEGs involved | P value |
|---|---|---|---|---|---|---|
| Glutamatergic synapse (chx04724) | 21 | 8.98054E-07 | Antigen processing and presentation (chx04612) | 6 | 0.001234391 | |
| Adherens junction (chx04520) | 15 | 2.05829E-05 | Systemic lupus erythematosus (chx05322) | 7 | 0.004038687 | |
| Inflammatory mediator regulation of TRP channel (chx04750) | 17 | 5.60775E-05 | EGFR tyrosine kinase inhibitor resistance (chx01521) | 5 | 0.007151845 | |
| Axon guidance (chx04360) | 23 | 8.68786E-05 | Fatty acid elongation (chx00062) | 3 | 0.008275261 | |
| Long-term depression (chx04730) | 12 | 9.18081E-05 | SMAD3,PDGFC | Asthma (chx05310) | 3 | 0.01251151 |
| Oxytocin signaling pathway (chx04921) | 21 | 9.7458E-05 | Inflammatory bowel disease (chx05321) | 4 | 0.016331757 | |
| Arrhythmogenic right ventricular cardiomyopathy (chx05412) | 13 | 0.000158767 | Leishmaniasis (chx05140) | 4 | 0.023108939 | |
| Aldosterone synthesis and secretion (chx04925) | 14 | 0.000169753 | Selenocompound metabolism (chx00450) | 2 | 0.026689839 | |
| Rap1 signaling pathway (chx04015) | 23 | 0.000689252 | TGF-beta signaling pathway (chx04350) | 4 | 0.029163353 | |
| Gap junction (chx04540) | 12 | 0.002506112 | FoxO signaling pathway (chx04068) | 5 | 0.037441899 |
Overlapped genes, the genes that are enriched in significant pathways as both DMGs and DEGs.