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(A) Visualization of the importance of different nucleotides and epigenetic features at different positions for our model trained on the benchmark dataset. The colors represent the contribution of the position-specific nucleotides to determining an efficient gRNA. The x-axis shows the positions of the nucleotide in the sequence. The y-axis lists all possible nucleotides. This representation also applies to. (B) Preference of nucleotide sequences that impact CRISPR/Cas9 gRNAs activity.
