Table 1.

Performance comparison between CNN-SVR and CNN models for gRNA activity prediction on four cell-line datasets under 10-time 10-fold cross-validation.

Model	CNN-SVR	CNN	CNN-SVR	CNN
	Spearman		AUROC
HCT116	0.719 ± 0.008	0.661 ± 0.030	0.933 ± 0.001	0.932 ± 0.001
HEK293T	0.807 ± 0.016	0.725 ± 0.029	0.983 ± 0.002	0.972 ± 0.001
HELA	0.699 ± 0.006	0.702 ± 0.007	0.933 ± 0.001	0.916 ± 0.001
HL60	0.589 ± 0.006	0.576 ± 0.040	0.934 ± 0.003	0.914 ± 0.003

Performance is shown as mean ± standard deviation. This representation also applies to Table 2. The best performance across different folds cross-validation method is highlighted in bold for clarification. These highlights also apply to Tables 2 to 4 and Tables S3 to S5.