Table 4.

AUROC of different deep learning-based methods by considering gRNA sequence only and incorporating both gRNA sequence and epigenetic features.

Model	HCT116	HEK293T	HELA	HL60	Average
(A) Sequence-only
CNN-SVR	0.938	0.976	0.930	0.928	0.943
DeepCRISPR	0.887	0.474	0.788	0.584	0.683
Seq-deepCpf1	0.931	0.976	0.925	0.920	0.938
(B) Sequence composition and epigenetic features
CNN-SVR	0.939	0.979	0.932	0.938	0.947
DeepCRISPR	0.919	0.506	0.820	0.643	0.722