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. 2019 Dec 27;11(12):761–772. doi: 10.4254/wjh.v11.i12.761

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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Consort diagram. Consort diagram for the study. Modulator refers to lumacaftor/ivacaftor use. CF: Cystic fibrosis, MRI: Magnetic resonance imaging; CFTR: Cystic fibrosis transmembrane conductance regulator.