Table 7. Diagnostic Performance of Simulated Biopsy Criteria in KTA/KSThR, ATA, and ACR Guidelines.
| Simulated Biopsy Criteria | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) | Unnecessary FNA Rate (%) |
|---|---|---|---|---|---|---|
| Criteria 1 | ||||||
| KTA/KSThR* | 94.5/100 | 26.4/28.0 | 27.4/22.4 | 94.2/100 | 41.9/40.4 | 56.9/59.6 |
| ATA* | 93.8/99.0 | 27.9/28.0 | 27.7/22.3 | 93.9/99.3 | 42.9/40.3 | 55.7/59.6 |
| ACR | 93.4/96.0 | 37.3/37.1 | 30.4/24.1 | 95.1/97.8 | 50.1/47.3 | 48.5/52.0 |
| Criteria 2 | ||||||
| KTA/KSThR | 90.5/97.0 | 43.3/43.9 | 31.9/26.5 | 94.0/98.6 | 54.1/53.1 | 43.8/46.4 |
| ATA | 90.5/97.0 | 41.7/40.4 | 31.3/25.3 | 93.8/98.5 | 52.8/50.2 | 45.1/49.3 |
| ACR | 90.3/94.1 | 48.4/48.9 | 34.0/27.7 | 94.5/97.5 | 58.0/56.7 | 39.9/42.3 |
| Criteria 3 | ||||||
| KTA/KSThR | 76.9/85.1 | 55.2/57.9 | 33.5/29.7 | 89.0/94.9 | 60.1/62.6 | 34.7/34.8 |
| ATA | 78.9/86.1 | 53.2/53.4 | 33.1/27.8 | 89.5/94.9 | 59.0/59.0 | 36.2/38.6 |
| ACR | 75.6/80.2 | 61.4/63.9 | 36.5/31.6 | 89.5/93.9 | 64.7/66.7 | 29.8/29.9 |
| Criteria 4 | ||||||
| KTA/KSThR | 75.6/85.1 | 63.7/66.4 | 37.9/34.5 | 89.9/95.5 | 66.4/69.6 | 28.1/27.8 |
| ATA | 77.5/86.1 | 62.2/62.7 | 37.6/32.5 | 90.4/95.6 | 65.7/66.7 | 29.2/30.9 |
| ACR* | 74.7/80.2 | 67.3/68.9 | 40.2/34.9 | 90.1/94.4 | 69.0/70.8 | 25.3/25.8 |
Data are diagnostic values of dataset 1 (n = 2000)/diagnostic values of dataset 2 (n = 586). *Original biopsy size criteria of each guideline. FNA = fine-needle aspiration, NPV = negative predictive value, PPV = positive predictive value