. Author manuscript; available in PMC: 2021 Jun 1.

Published in final edited form as: CNS Spectr. 2019 Jul 15;25(6):743–749. doi: 10.1017/S1092852919001093

Table 1.

Effects of allostatic load, PTSD, and cannabinoid agonist on measures of allotasis.

Allostaticmeasure	Allostatic load effect	Observation in PTSD	Cannabinoid effect
Metabolic
HDL	↓	↓^15,74,75	↑^28–30
LDL	↑	↓^15,76	↓^29,30
Triglycerides	↑	↑^15,75,77	↓^29,30
IR	↑	↑⁷⁸	↑↓^28,31
BMI	↑	↑^15,19,75	↓^29,32,33
WHR	↑	↑⁷⁹	↓^29,34
Inflammatory
CRP	↑	↑↓^78,80	↓^30,38,39
IL-6	↑	↑^21,78	↓^43,81
TNF-α	↑	↑²¹	↓^40,41
Cardiovascular
Heart rate	↑	↑^78,82	↑↓^44,46
Heart rate variability	↓	↓²⁰	↑⁴⁸
DBP	↑	↑^44,75,82,83	↑↓^29,44,84
SBP	↑	↑^75,82,83	↑↓^29,44,84
Neuroendocrine
Cortisol/glucocorticoids	↑	↑↓^19,21,85	↓^49–53
NE	↑	↑^19,86	↑↓^{58–62,87,88}
DA	↑	↑⁸⁶	↑↓^54–57