Table1.
Clinical Characteristics of Mayo Cohort
| Diabetes (+) (N=253) | Diabetes (–) (N=101) | P | |
|---|---|---|---|
| Age | 61.5 ± 9.3 | 61.5 ± 11.1 | 0.98 |
| Gender (Male) | 104 (41.1%) | 41 (40.6%) | 0.93 |
| Race (White) | 233 (92.1%) | 100 (99.0%) | 0.013 |
| Ascites | 0.50 | ||
| None | 168 (66.4%) | 61 (60.4%) | |
| Mild to Moderate (diuretic responsive) | 71 (28.1%) | 32 (31.7%) | |
| Severe (diuretic refractory) | 14 (5.5%) | 8 (7.9%) | |
| Hepatic Encephalopathy | 0.78 | ||
| None | 216 (85.7%) | 87 (86.1%) | |
| Grade 1–2 | 35 (13.9%) | 13 (12.9%) | |
| Grade 3–4 | 1 (0.4%) | 1 (1.0%) | |
| Fasting glucose | 141.8 ± 56.1 | 99.3 ± 12.6 | <0.001 |
| HbA1c | 7.6 ± 9.5 | 5.2 ± 0.5 | <0.001 |
| INR | 1.2 ± 0.3 | 1.3 ± 0.5 | 0.21 |
| Albumin | 3.7 ± 0.7 | 3.7 ± 0.6 | 0.62 |
| Creatinine | 1.0 ± 0.7 | 1.0 ± 0.7 | 0.93 |
| Bilirubin | 1.1 ± 0.9 | 1.7 ± 1.9 | 0.019 |
| Platelet count, median (IQR) | 114.5 (85, 170) | 121.5 (80.3, 169.8) | 0.98 |
| CTP score | 7.5 ± 1.1 | 7.8 ± 1.2 | 0.018 |
| A (5–6) | 28 (12.2%) | 4 (4.3%) | |
| B (7) | 120 (51.9%) | 47 (51.1%) | |
| B (8–9) | 68 (29.4%) | 32 (34.8%) | |
| C (≥10) | 15 (6.5%) | 9 (9.7%) | |
| MELD score | 10.2 ± 4.2 | 11.0 ± 5.5 | 0.49 |
| Hypertension | 201 (79.4%) | 59 (58.4%) | <0.001 |
| Hyperlipidemia | 195 (78.3%) | 70 (69.3%) | 0.075 |
| BMI, body mass index | 38.2 ± 19.9 | 34.8 ± 9.6 | 0.10 |
| Obesity (BMI≥ 30) | 203 (81.5%) | 75 (75.0%) | 0.22 |
| Cigarette smoking (Ever) | 113 (45.0%) | 33 (33.0%) | 0.052 |
| Bariatric surgery | 13 (5.1%) | 5 (5.0%) | 0.94 |
| Diabetes medication | |||
| Metformin | 128 (51.0%) | - | |
| Insulin | 107 (42.6%) | - | |
| Sulfonylurea | 79 (31.5%) | - | |
| HCC | 27 | 3 |
Clinical data including medical and surgical history, ascites, hepatic encephalopathy, and laboratory result were collected at the time of initial cirrhosis evaluation.