Table 1.
Population demographic and tumor characteristics for children with germ cell tumors by race/ethnicity and sex, SEER 18 2000-2015
| Males | Females | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Non- Hispanic White |
Black | Asian/ Pacific Islander |
Hispanic | Non- Hispanic White |
Black | Asian/ Pacific Islander |
Hispanic | |||
| N (%) 1241 (51.0) |
N (%) 77 (3.2) |
N (%) 208 (8.6) |
N (%) 906 (37.3) |
N (%) 395 (44.8) |
N (%) 137 (15.5) |
N (%) 97 (11.0) |
N (%) 253 (28.7) |
|||
| n (%) | n (%) | n (%) | n (%) | chi-squared p-value |
n (%) | n (%) | n (%) | n (%) | chi-squared p-value |
|
| Age at diagnosis (years) | ||||||||||
| Average (Standard Deviation) | 15.8 (4.5) | 14.6 (5.5) | 13.9 (5.7) | 15.4 (4.8) | 11.8 (6.0) | 12.0 (6.1) | 12.1 (5.6) | 12.9 (5.0) | ||
| <1 | 22 (1.8) | 3 (3.9) | 8 (3.8) | 21 (2.3) | 0.003 | 18 (4.6) | 11 (8.0) | 5 (5.2) | 6 (2.4) | 0.08 |
| 1-4 | 54 (4.4) | 6 (7.8) | 19 (9.1) | 48 (5.3) | 50 (12.7) | 12 (8.8) | 9 (9.3) | 16 (6.3) | ||
| 5-9 | 33 (2.7) | 1 (1.3) | 8 (3.8) | 27 (3.0) | 53 (13.4) | 12 (8.8) | 10 (10.3) | 30 (11.9) | ||
| 10-14 | 138 (11.1) | 12 (15.6) | 38 (18.3) | 100 (11.0) | 106 (26.8) | 37 (27.0) | 34 (35.1) | 81 (32.0) | ||
| 15-19 | 994 (80.1) | 55 (71.4) | 135 (64.9) | 710 (78.4) | 168 (42.5) | 65 (47.4) | 39 (40.2) | 120 (47.4) | ||
| Tumor Location | ||||||||||
| Intracranial/Intraspinal | 237 (19.1) | 31 (40.3) | 89 (42.8) | 137 (15.1) | <0.0001 | 61 (15.4) | 18 (13.1) | 34 (35.1) | 34 (13.4) | <0.0001 |
| Extracranial/Extragonadal | 58 (4.7) | 8 (10.4) | 31 (14.9) | 66 (7.3) | 83 (21.0) | 46 (33.6) | 17 (17.5) | 44 (17.4) | ||
| Gonadal | 946 (76.2) | 38 (49.4) | 88 (42.3) | 703 (77.6) | 251 (63.5) | 73 (53.3) | 46 (47.4) | 175 (69.2) | ||
| Tumor Histology | ||||||||||
| Germinoma | 361 (29.1) | 37 (48.1) | 105 (50.5) | 248 (27.4) | <0.0001 | 187 (47.3) | 38 (27.7) | 51 (52.6) | 117 (46.2) | 0.0002 |
| Yolk sac tumor | 80 (6.4) | 11 (14.3) | 37 (17.8) | 89 (9.8) | 92 (23.3) | 41 (29.9) | 26 (26.8) | 48 (19.0) | ||
| Mixed | 613 (49.4) | 20 (26.0) | 51 (24.5) | 447 (49.3) | 91 (23.0) | 36 (26.3) | 13 (13.4) | 64 (25.3) | ||
| Other | 187 (15.1) | 9 (11.7) | 15 (7.2) | 122 (13.5) | 25 (6.3) | 22 (16.1) | 7 (7.2) | 24 (9.5) | ||
| Tumor size (cm) | ||||||||||
| ≤2 | 202 (23.6) | 10 (21.7) | 22 (15.9) | 103 (15.4) | <0.0001 | 21 (8.8) | 7 (8.5) | 4 (6.6) | 10 (6.4) | 0.06 |
| >2-≤5 | 434 (50.7) | 29 (63.0) | 76 (55.1) | 303 (45.2) | 40 (16.7) | 8 (9.8) | 19 (31.1) | 27 (17.2) | ||
| >5 | 220 (25.7) | 7 (15.2) | 40 (29.0) | 265 (39.5) | 179 (74.6) | 67 (81.7) | 38 (62.3) | 120 (76.4) | ||
| missing | 385 | 31 | 70 | 235 | 155 | 55 | 36 | 96 | ||
| Stage of disease | ||||||||||
| Local | 784 (64.6) | 43 (58.9) | 129 (64.2) | 497 (56.3) | 0.002 | 167 (44.9) | 52 (40.3) | 55 (57.3) | 105 (43.0) | 0.02 |
| Regional | 245 (20.2) | 16 (21.9) | 43 (21.4) | 194 (22.0) | 127 (34.1) | 36 (27.9) | 20 (20.8) | 70 (28.7) | ||
| Distant | 185 (15.2) | 14 (19.2) | 29 (14.4) | 192 (21.7) | 78 (21.0) | 41 (31.8) | 21 (21.9) | 69 (28.3) | ||
| missing | 27 | 4 | 7 | 23 | 23 | 8 | 1 | 9 | ||
| Surgery (yes) | 1073 (86.5) | 62 (80.5) | 139 (66.8) | 792 (87.4) | 334 (84.6) | 115 (83.9) | 71 (73.2) | 214 (84.6) | ||
| Radiation (yes) | 246 (19.8) | 32 (41.6) | 78 (37.5) | 144 (15.9) | 51 (12.9) | 14 (10.2) | 27 (27.8) | 30 (11.9) | ||
| Chemotherapy (yes) | 667 (53.7) | 44 (57.1) | 133 (63.9) | 526 (58.1) | 277 (70.1) | 96 (70.1) | 74 (76.3) | 182 (71.9) | ||
| Vital status | ||||||||||
| Alive | 1172 (94.4) | 70 (90.9) | 181 (87.0) | 810 (89.4) | <0.0001 | 369 (93.4) | 128 (93.4) | 89 (91.8) | 241 (95.3) | 0.6 |
| Dead | 69 (5.6) | 7 (9.1) | 27 (13.0) | 96 (10.6) | 26 (6.6) | 9 (6.6) | 8 (8.2) | 12 (4.7) | ||
| Year diagnosed | ||||||||||
| 2000:2004 | 394 (31.7) | 30 (39.0) | 59 (28.4) | 200 (22.1) | <0.0001 | 136 (34.4) | 41 (29.9) | 26 (26.8) | 75 (29.6) | 0.5 |
| 2005:2009 | 419 (33.8) | 23 (29.9) | 58 (27.9) | 283 (31.2) | 116 (29.4) | 40 (29.2) | 34 (35.1) | 71 (28.1) | ||
| 2010:2015 | 428 (34.5) | 24 (31.2) | 91 (43.8) | 423 (46.7) | 143 (36.2) | 56 (40.9) | 37 (38.1) | 107 (42.3) | ||