Table 3:
Characteristics of individuals with Lynch syndrome
| Carriers with a personal history of gastric cancer (N=41) | Carriers without a personal history of gastric cancer (N=3787) | P value | |
|---|---|---|---|
| N (%) | N (%) | ||
| Male | 25 (61.0) | 1372 (36.2) | 0.002 |
| Female | 16 (39.0) | 2415 (63.8) | |
| Median age at germline testing, yrs (IQR) | 61.0 (56.0, 73.0) | 50.0 (41.0, 58.0) | <0.001 |
| Median age at gastric cancer diagnosis, yrs (IQR)* | 56.5 (49.25, 65.5) | - | - |
| Race | |||
| Caucasian/White | 22(53.7) | 2249 (59.4) | 0.560 |
| African American/Black | 2 (4.9) | 183 (4.8) | >0.99 |
| Asian | 2 (4.9) | 109 (2.9) | 0.771 |
| Other/Multiple | 8 (19.5) | 520 (13.7) | 0.401 |
| Missing/No Answer | 7 (17.1) | 726 (19.2) | 0.889 |
| MMR gene mutation | 0.115 | ||
| MLH1 | 19 (46.3) | 1327 (35.0) | 0.179 |
| MSH2 | 20 (48.8) | 1619 (42.8) | 0.537 |
| MSH6 | 2 (4.9) | 668 (17.6) | 0.036 |
| PMS2 | 0 (0.0) | 145 (3.8) | 0.406 |
| EPCAM | 0 (0.0) | 28 (0.7) | >0.99 |
| Personal history of Lynch syndrome spectrum cancer | |||
| Any Lynch syndrome spectrum cancer (except gastric) | 37 (90.2) | 3145 (83.0) | 0.29 |
| Colorectal cancer | 35 (85.4) | 2461 (65.0) | 0.005 |
| Endometrial cancer** | 5/16 (31.3) | 903/2415 (37.4) | 0.080 |
| Ovarian cancer** | 0/16 (0.0) | 194/2415 (8.0) | 0.63 |
| Pancreatic cancer | 0 (0.0) | 23 (0.6) | 1.00 |
| Small bowel cancer | 0 (0.0) | 56 (1.5) | 1.00 |
| Urinary tract cancer | 5 (12.2) | 153 (4.0) | 0.025 |
| Other Lynch syndrome spectrum cancer*** | 6 (14.6) | 160 (4.2) | 0.008 |
| Family history of Lynch syndrome spectrum cancer**** | |||
| Gastric cancer | 11 (26.8) | 339 (9.0) | <0.001 |
| Colorectal cancer | 28 (68.3) | 2969 (78.4) | 0.170 |
| Endometrial cancer | 12 (29.3) | 954 (25.2) | 0.677 |
| Ovarian cancer | 5 (12.2) | 406 (10.7) | 0.798 |
| Pancreatic cancer | 7 (17.1) | 246 (6.5) | 0.016 |
| Small bowel cancer | 1 (2.4) | 69 (1.8) | 0.533 |
| Urinary tract cancer | 6 (14.6) | 363 (9.6) | 0.281 |
*
Age at gastric cancer diagnosis missing for 3 Lynch syndrome carriers
**
Denominator is for female carriers only
***
Includes hepatobiliary cancers, brain cancers/gliomas, and sebaceous neoplasms of the skin
****
First- and second-degree relatives