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. 2019 Dec 20;19(2):1267–1272. doi: 10.3892/ol.2019.11237

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Copyright: © Qiu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — miRNA-526b influences proliferative and migratory abilities of NSCLC by downregulating EZH2. (A) Binding sites between EZH2 and miRNA-526b. (B) Luciferase activity in A549 cells co-transfected with miRNA-526b mimic/NC and EZH2 WT/EZH2 MT. (C) EZH2 level in A549 cells transfected with NC or miRNA-526b mimic. (D) Viability in A549 cells transfected with NC, miRNA-526b mimic or miRNA-526b mimic + pcDNA EZH2. (E) Wound closure in A549 cells transfected with NC, miRNA-526b mimic or miRNA-526b mimic + pcDNA EZH2 at 0 and 24 h (magnification, ×40). PVT1, plasmacytoma variant translocation 1; NSCLC, non-small cell lung cancer. ***P<0.001.