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. 2019 Dec 31;19(2):1418–1426. doi: 10.3892/ol.2019.11246

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — (Ab and Bb) Suppression of BRD4 influences miR-608-induced apoptosis. (Aa-f) In Panc-1 cell line, (Ad and Bd) compared with the control (NC group), (Aa) overexpression of miR-608 or (Ab) suppression of BRD4 separately as mimics or siBRD4 groups may significantly increase the level of apoptosis. (Ac) Simultaneously increasing the levels of miRNA-608 and BRD4 mRNA may significantly decrease the level of apoptosis induced by the overexpression of miRNA-608. (Ae) There is the statistical result of the percentage of apoptosis in different level of miR-608 and BRD4 expression. (Af) It also shows the knock down result of siBRD4 in protein level. (Ba-f) In the Bxpc-3 cell line, similar results are obtained. (Ba) Overexpression of miR-608 (mimics group) or (Bb) suppression of BRD4 (siBRD4 group) significantly increase the level of apoptosis than that in (Bd) control (NC group). (Bc) Overexpression of BRD4 may subtract the increased apoptosis induced by miR-608. (Be and f) There are the percentage of apoptosis and BRD4 knock down efficiency. *P<0.05 and ***P<0.001. miRNA, microRNA. siBRD4, small interfering bromodomain-containing protein 4.

Figure 5. — (Ab and Bb) Suppression of BRD4 influences miR-608-induced apoptosis. (Aa-f) In Panc-1 cell line, (Ad and Bd) compared with the control (NC group), (Aa) overexpression of miR-608 or (Ab) suppression of BRD4 separately as mimics or siBRD4 groups may significantly increase the level of apoptosis. (Ac) Simultaneously increasing the levels of miRNA-608 and BRD4 mRNA may significantly decrease the level of apoptosis induced by the overexpression of miRNA-608. (Ae) There is the statistical result of the percentage of apoptosis in different level of miR-608 and BRD4 expression. (Af) It also shows the knock down result of siBRD4 in protein level. (Ba-f) In the Bxpc-3 cell line, similar results are obtained. (Ba) Overexpression of miR-608 (mimics group) or (Bb) suppression of BRD4 (siBRD4 group) significantly increase the level of apoptosis than that in (Bd) control (NC group). (Bc) Overexpression of BRD4 may subtract the increased apoptosis induced by miR-608. (Be and f) There are the percentage of apoptosis and BRD4 knock down efficiency. *P<0.05 and ***P<0.001. miRNA, microRNA. siBRD4, small interfering bromodomain-containing protein 4.