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. 2020 Jan 8;10:3032. doi: 10.3389/fimmu.2019.03032

Figure 3.

Figure 3

CD36 deficiency prevents pathogenic subretinal inflammation in acute, light-induced Cx3cr1-knockout mice. (A) Schematic representation of the light-challenge model. (B) Representative images and quantification of IBA-1 (green) stained RPE flatmounts of 2 month-old mice of the indicated strains after 10 days after the light-challenge (*Mann & Whitney test C57BL/6J control mice vs. Cx3cr1−/− mice p = 0.0014; $Mann & Whitney test Cx3cr1−/− vs. Cx3cr1−/−Cd36−/− mice p = 0.02). (C) Representative images and quantification of TUNEL+ cells in the outer nuclear layer of TUNEL-stained retinal flatmounts of d14 light-challenged mice of the indicated strains (*Mann & Whitney test C57BL/6J control mice vs. Cx3cr1−/− mice p = 0.0005; $Mann & Whitney test Cx3cr1−/− vs. Cx3cr1−/−Cd36−/− mice p = 0.0012). n, indicated for each bar; Scale bar (A) = 50 μm.