Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 8;13:1381. doi: 10.3389/fnins.2019.01381

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Ebanks, Lewis and Bandopadhyay.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Figure depicting the possible role of the discussed mechanisms as upstream effectors in the generation of α-synuclein aggregation and Lewy body formation. (1) showing the genes involved in the trans-golgi network; (2) in endocytosis and exocytosis; (3) lysosomal genes and (4) the generation of α-synuclein oligomers leading to the formation of (5) Lewy bodies. The precise point at which cytotoxicity occurs in the brain is not clear. Image of α-synuclein fibrils (4) is modified from Li et al. (2018) using a Creative Commons license.