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. 2020 Jan 8;10:2957. doi: 10.3389/fmicb.2019.02957

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Copyright © 2020 Zhou, Liu, Zhang, Liao, Sun and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Efficacy of colistin and tigecycline mono- and combination therapies at 24 h against E. coli ATCC 25922 (A), 2630 (B), 3112 (C) and strains harboring bla_NDM–5 and mcr-1 (D–F) in the murine thigh infection model with a high initial burden of 10⁸ cfu/thigh. Colistin (7.5 mg/kg i.p. bid) and tigecycline (5 mg/kg s.c. bid) and the combination were administrated at 2 h post-infection. Horizontal lines represent the mean and standard deviation of bacterial densities for each group (n = 6). Colistin and tigecycline combination therapy resulted in a >2.5 log₁₀cfu/thigh reduction relative to each monotherapy (P < 0.0005, Mann-Whitney U-test).