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. 2020 Jan 15;31(2):118–130. doi: 10.1091/mbc.E19-03-0179

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© 2020 Brunner et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 7: — AMOT130 modulates BMP-SMAD signaling by enhanced trafficking at the apical membrane of polarized cells. AMOT130 associates to the BMP receptor complex and SMAD1. On BMP stimulation, AMOT130 is dephosphorylated and subsequently internalized. Increased trafficking of AMOT130 leads to more SMAD1/5 phosphorylation and subsequently more SMAD1/SMAD4 complex formation. These complexes translocate to the nucleus and activate target gene transcription, e.g., ID1. As AMOT is predominantly expressed apically, it facilitates only apical BMP-SMAD signaling and thereby only a subpopulation of receptor complexes. The proposed transmembrane topology was proven by surface biotinylation assays (box) (Bratt et al., 2005).