Table 2. Hippocampal subfield volumes (mm3) of participants in baseline.
| Anatomical region | PD (N=28) | Control (N=27) | Statistic (F) | P value |
|---|---|---|---|---|
| Left | ||||
| Total hippocampus | 3,410.48±311.99 | 4,181.58±397.34 | 64.334 | <0.001* |
| Parasubiculum | 55.17±9.3 | 56.90±9.96 | 0.438 | 0.511 |
| Presubiculum | 300.41±39.25 | 304±36.11 | 0.174 | 0.678 |
| Subiculum | 430.62±53.02 | 482.32±41.43 | 16.154 | <0.001* |
| CA1 | 605.52±66.26 | 618.95±52.76 | 0.688 | 0.411 |
| CA2/3 | 208.98±24.34 | 221.89±16.04 | 5.353 | 0.025* |
| CA4 | 273.03±31.45 | 312.92±32.32 | 21.503 | <0.001* |
| GC-DG | 305.76±35.91 | 325.38±37.83 | 3.891 | 0.054 |
| ML | 571.48±57.34 | 634.49±53.10 | 17.842 | <0.001* |
| Fimbria | 77.19±20.99 | 86.13±22.61 | 2.308 | 0.135 |
| Fissure | 175.36±32.44 | 191.26±25.25 | 4.094 | 0.065 |
| HATA | 50.73±5.97 | 52.97±4.81 | 2.333 | 0.133 |
| Hippocampal tail | 531.54±53.26 | 554.50±37.48 | 0.626 | 0.433 |
| Right | ||||
| Total hippocampus | 3,629.44±319.92 | 4,181.58±397.34 | 6.829 | 0.012* |
| Parasubiculum | 56.60±9.52 | 63.00±8.41 | 6.939 | 0.011* |
| Presubiculum | 297.13±40.75 | 311.34±33.44 | 1.990 | 0.164 |
| Subiculum | 440.28±50.02 | 487.89±38.08 | 15.682 | <0.001* |
| CA1 | 643.09±70.93 | 676.19±53.82 | 3.780 | 0.057 |
| CA2/3 | 239.07±30.69 | 255.58±17.37 | 5.969 | 0.018* |
| CA4 | 304.58±34.62 | 337.99±27.19 | 15.750 | <0.001* |
| GC-DG | 332.37±34.38 | 373.96±45.13 | 14.838 | <0.001* |
| ML | 611.05±54.45 | 655.07±49.28 | 9.855 | 0.003* |
| Fimbria | 64.18±18.53 | 64.94±14.09 | 0.005 | 0.943 |
| Fissure | 179.84±33.12 | 186.10±27.61 | 0.578 | 0.450 |
| HATA | 51.66±7.72 | 55.35±4.63 | 4.556 | 0.057 |
| Hippocampal tail | 588.92±57.06 | 597.19±41.40 | 0.376 | 0.542 |
*, P<0.05. The P value was calculate using ANCOVA, controlling for age, sex, education, and intracranial volume (ICV). CA, cornus ammonis; GC-DG, granule cell layer of dentate gyrus; M, molecular layer; HATA, hippocampus-amygdala transition area; PD, Parkinson’s disease.