Table 1.
Distribution of genotypes at weaning from a breeding to generate low-TF;FIX−/− offspring
| Sex | mTF | hTF | FIX | Expected, % | E14.5, n | E14.5 observed, % | E14.5 O/E, % | P1, n | P1 observed, % | P1 O/E, % | P21, n | P21 observed, % | P21 O/E, % |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| F | +/− | +/(+/−) | +/+ | 12.5 | 7 | 18.4 | 147 | 3 | 6.6 | 52 | 15 | 18.5 | 148 |
| F | +/− | +/(+/−) | +/− | 12.5 | 7 | 18.4 | 147 | 7 | 15.5 | 147 | 13 | 16.0 | 128 |
| M | +/− | +/(+/−) | +/y | 12.5 | 1 | 2.6 | 21 | 10 | 22.2 | 178 | 15 | 18.5 | 148 |
| M | +/− | +/(+/−) | −/y | 12.5 | 4 | 10.5 | 84 | 8 | 17.7 | 142 | 9 | 11.1 | 89 |
| F | −/− | +/(+/−) | +/+ | 12.5 | 5 | 13.2 | 106 | 4 | 8.8 | 70 | 8 | 9.9 | 79 |
| F | −/− | +/(+/−) | +/− | 12.5 | 5 | 13.2 | 106 | 2 | 4.4 | 35 | 12 | 14.8 | 118 |
| M | −/− | +/(+/−) | +/y | 12.5 | 5 | 13.2 | 106 | 6* | 13.3 | 106 | 9 | 11.1 | 89 |
| M | −/− | +/(+/−) | −/y | 12.5 | 4 | 10.5 | 84 | 5† | 11.1 | 89 | 0 | 0 | 0‡ |
| Total | 100.0 | 38 | 100.0 | — | 45 | 100.0 | — | 81 | 100.0 | — | |||
F, female; hTF+/(+/−), hTF+/− or hTF+/+; M, male; O/E, observed/expected.
*
One of 6 dead.
†
Two of 5 dead.
‡
P < .05 observed vs expected, 2-tailed Fisher’s exact test.