Table 3.
Observed low-TF;FXI−/− offspring at weaning from additional breedings and death of females
| Breeding type | Expected, % | Dam FXI genotype | Death/pregnancy, n/n (%) | Survived | Died | ||
|---|---|---|---|---|---|---|---|
| n/N at P21 (litters) | Observed, % | n/N at E13-15.5 (litters) | Observed, % | ||||
| 1 | 4.69 | +/− | 2/23 (9) | — | — | — | — |
| 2 | 10.26 | +/− | 2/5 (40) | 1/25 (3) | 4.0 | 4/14 (2)* | 29.0 |
| 3 | 10.26 | +/− | 2/10 (20) | 3/40 (6) | 7.5 | 7/19 (2)* | 37.0 |
| 4 | 10.26 | −/− | 2/6 (33) | 2/19 (3) | 10.5 | 2/7 (1) | 29.0 |
| 5 | 20.52 | −/− | 3/10 (30) | 3/22 (7) | 13.6 | 6/17 (3) | 35.3 |
*
P < .05, difference in observed frequency of mTF−/−;hTF+/(+/−);FXI−/− in surviving mothers vs dead mothers assessed by 2-tailed Fisher’s exact test.