Table 4.

Calcium sensitivity of tension

	NF	NF+PKA	DCM	DCM+PKA
N, n	8, 33	8, 30	8, 28	8, 24
EC50, μM	2.75 (2.21–3.20)	3.10 (2.15–3.50)	1.86 (1.52–2.75)**	3.00 (2.63–3.85)#
pCa50	5.59 ± 0.0271	5.53 ± 0.0281	5.70 ± 0.0291**	5.46 ± 0.0430#
Hill coefficient nH	1.94 (1.36–2.86)	2.19 (1.38–3.20)	1.56 (1.31–1.94)*	2.14 (1.31–2.61)
Peak tension, mN/mm2	32.8 (21.5–49.2)	31.6 (23.1–50.7)	29.7 (21.6–47.0)	31.6 (19.1–45.3)

Normally distributed data are means ± SE and nonparametric data as medians (interquartile range) for N subjects and n cardiomyocytes. DCM, dilated cardiomyopathy; NF, nonfailing; PKA, protein kinase A. Different from NF:

^*P < 0.05,

^**P < 0.01. Different from DCM without PKA:

^#P < 0.0001.