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. 2019 Oct 21;317(6):F1649–F1655. doi: 10.1152/ajprenal.00395.2019

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Fig. 3. — A: morphology of polycystic kidneys collected from polycystic kidney (PCK) rats demonstrating reduced cyst development in P2X7 receptor (P2rx7)-deficient animals. PCK.P2rx7^+/+, PCK rats with intact P2rx7; PCK.P2rx7^−/−, PCK rats with P2rx7^−/− knockout; PCK.P2rx7^+/−, PCK rats heterozygous for P2rx7^−/−. B: glomerular morphology in 9- and 28- week-old littermates showing the progressive development of glomerulopathy. Yellow line denotes massive infiltration of immune cells typical in old animals. C: summary graph of the ratio of cyst area to total slice area in littermates of all 3 genotypes. D: number of individual cysts detected in representative kidney slices. E: contribution of cysts of each of 3 sizes of total cyst area. *P < 0.05.