. 2020 Feb 1;30(3):126751. doi: 10.1016/j.bmcl.2019.126751

Table 3.

Notum inhibition of thieno- (6–12), pyrrolo- (13–16), pyrazolo- (17) and furanopyrimidine acids (18–19).

Compound	Notum IC₅₀ (nM)^a	Compound	Notum IC₅₀ (nM)^a
	790 ± 70^b		77,000 ± 28,000^b
	5.8 ± 0.5 ^b		20,000 ± 3,900
	2,100 ± 330		15,000 ± 1,700
	1.0 ± 0.4		50,000 ± 6,500
	3.9 ± 0.7		1,100 ± 240
	25 ± 4		50 ± 14^b
	8.1 (n = 1)		3.2 ± 0.5

See footnotes Table 1.

Notum IC₅₀ values for published compounds 6, 7, 13, 18 are presented for comparison in a common assay format and to define SAR relationships: 6, 152 nM; 7, 2 nM; 13, 15,000 nM; 18, not disclosed. See, Ref. 10.