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. 2019 Nov 13;2(4):85. doi: 10.3390/mps2040085

Figure 18.

Figure 18

Codon distribution of TP53 mutations (A) induced by BaP and BPDE in HUFs [11,15,25] and the spectrum found in lung cancer of (B) smokers, (C) non-smokers and (D) all cancers in exons 4–9. Reference for human cancer mutation distribution acquired from IARC TP53 mutation database, R20 July 2019 [48]. Exclusions for lung cancer mutation distribution: radon, asbestos, mustard gas, and coal [49,50]. Mutation hotspots are indicated in grey.