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. Author manuscript; available in PMC: 2021 Feb 20.
Published in final edited form as: Free Radic Biol Med. 2019 Dec 26;148:70–82. doi: 10.1016/j.freeradbiomed.2019.12.037

Figure 7: Accumulation of nuclear CHOP is associated with impaired IL-13 secretion by adipocytes.

Figure 7:

(A) The nuclear fraction from adipocytes cultured in 5 or 25 mM glucose demonstrates elevated nuclear CHOP levels during glucotoxicity. (B) Serum free conditioned medium was collected from adipocytes matured in normal or high glucose +/− 5 mM NAC and IL-13 levels were quantified (n=3/group, mean +/− SEM, *p< 0.05). (C) Confirmation of elevated CHOP protein levels in adipose tissue of 15 week old db/db (n=3 representative), in which IL-13 was quantified in (D) adipose tissue, p=0.004** and (E) serum, n=5 controls, n=6 db/db mice per group for the IL-13 quantification, normalized to protein levels.