Effect of the neutral single point mutations on the elasticity of the TPR domain. A) End-to-end distance of the OGT-TPR domain of the L254I mutant (grey), A310T mutant (green) and I279V mutant (pink). B) Equilibrium structures of the wild-type and negative control OGT-TPR domains. The wild-type, L254I, I279V and A310T TPR domains are shown as blue, grey, pink and green cartoon respectively. Mutations are highlighted in red spheres. The figure also shows the equilibrium end-to-end distances between TPR2 and the TPR11.