Fig. 7.

The molecular network of “HPTMs-reader proteins-binding proteins”. From the network, the tandem-domain-reader proteins could read different combinatorial HPTMs peptides and interact with nucleoproteins. The interactive nucleoproteins were separated into two parts based on function, namely, transcription and other functions. Among the 78 proteins, 14 proteins (HELLS, MBB1A, PRKDC, LBR, SFPQ, PSIP1, GTF2I, HLTF, TRIPC, RAD50, CDC73, DDX21, and PHF8) have functions related to transcription, and in particular, and 4 of these proteins (HELLS, MBB1A, PRKDC, and TRRAP) modified histones directly.