Table 2.
Ventilation settings and hemodynamics—standard protocol-based cohort and lung rescue team cohort
| Variable | Group | Day 1 | Day 2 | Day 3 | Day 4 | ||||
|---|---|---|---|---|---|---|---|---|---|
| PEEP, cmH2O , mean (CI 95%) | Standard protocol-based cohort | 9 (8–10) | P = 0.20 | 9 (8–10) | P < 0.001 | 9 (8–10) | P < 0.001 | 9 (8–10) | P < 0.001 |
| Lung rescue team cohort | 9 (9–10) | 19 (18–20) | 20 (18–21) | 20 (18–21) | |||||
| TV/IBW, mL/kg , mean (CI 95%) | Standard protocol-based cohort | 6.4 (6.2–6.6) | P = 0.33 | 6.5 (6.3–6.8) | P = 0.10 | 6.4 (6.1–6.6) | P = 0.21 | 6.5 (6.3–6.7) | P = 0.11 |
| Lung rescue team cohort | 6.2 (5.9–6.5) | 6.2 (5.9–6.5) | 6.2 (5.9–6.5) | 6.2 (5.9–6.6) | |||||
| DPa, cmH2O, mean (CI 95%) | Standard protocol-based cohort | 13 (12.1–14.1) | P = 0.94 | 13 (12.2–14.8) | P < 0.001 | 13 (11.9–15.2) | P < 0.001 | 13 (11.8–15.1) | P < 0.001 |
| Lung rescue team cohort | 13 (12.0–14.3) | 10 (8.7–10.4) | 9 (8.2–9.9) | 8 (7.3–9.6) | |||||
| CRSb, mL/cmH2O, mean (CI 95%) | Standard protocol-based cohort | 35 (31–38) | P = 0.41 | 33 (27–39) | P < 0.001 | 36 (27–46) | P = 0.003 | 33 (27–40) | P = 0.002 |
| Lung rescue team cohort | 33 (29.7–37.1) | 45 (41–49) | 48 (41–56) | 52 (42–62) | |||||
| Pa/FiO2, mmHg, mean (CI 95%) | Standard protocol-based cohort | 197 (177–217) | P = 0.003 | 224 (203–245) | P = 0.001 | 220 (199–242) | P = 0.004 | 218 (194–242) | P = 0.004 |
| Lung rescue team cohort | 154 (127–179) | 282 (252–312) | 284 (256–312) | 276 (243–309) | |||||
| RIV No. (%) | Standard protocol-based cohort | 49/70 (70) | P = 0.47 | 51/70 (73) | P = 0.30 | 41/70 (58) | P = 0.04 | 39/70 (56) | P = 0.005 |
| Lung rescue team cohort | 38/50 (76) | 32/50 (64) | 20/50 (40) | 15/50 (30) | |||||
| VIS , mean (CI 95%) | Standard protocol-based cohort | 16 (11–21) | P = 0.79 | 15 (10–20) | P = 0.14 | 14 (9–20) | P = 0.004 | 15 (6–24) | P = 0.001 |
| Lung rescue team cohort | 15 (9–21) | 9 (5–12) | 5 (2–8) | 4 (1–8) | |||||
Abbreviations: PEEP positive end-expiratory pressure, CI confidence interval, TV tidal volume, IBW ideal body weight, DP driving pressure, CRS compliance of respiratory system, RIV requirement for inotropics and vasopressors, VIS vasoactive-inotropic score
aDriving pressure is difference between plateau pressure (measured at the end of an end-inspiratory pause) and total positive end-expiratory pressure (measured at the end of an end-expiratory pause)
bRespiratory system compliance is the ratio of tidal volume to driving pressure
Information at days 3 and 4 were available for more than 80% of patients and statistics were performed only on available data