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. 2020 Jan 13;9:F1000 Faculty Rev-17. [Version 1] doi: 10.12688/f1000research.21295.1

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Copyright: © 2020 Lusvarghi S et al.

This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The author(s) is/are employees of the US Government and therefore domestic copyright protection in USA does not apply to this work. The work may be protected under the copyright laws of other jurisdictions when used in those jurisdictions.

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Figure 1. — The overall structure of ( A) taxol-bound P-glycoprotein (P-gp), ( B) leukotriene C4-bound multidrug resistance protein 1 (MRP1), and ( C) estrone-3-sulfate-bound ABCG2. Cartoon representation of the different transporters on the top panels and cartoon and surface representation of the binding cavity as observed from the cytosolic region in the bottom panels. TMD0 of MRP1 is colored in yellow, the N-terminal half of P-gp and MRP1 (transmembrane domain [TMD] 1 and nucleotide-binding domain [NBD] 1) are colored in green, and the corresponding C-terminal halves (TMD2 and NBD2) are colored in cyan. Each monomer of the homodimer of ABCG2 is colored in green or cyan. Ligands bound in the transmembrane region are shown in ball and stick format (gray, carbon; red, oxygen; blue, nitrogen).